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+0.08 Liver exerkine reverses Alzheimer's-related memory loss via vasculature (www.sciencedirect.com)
9 points by PaulHoule 1 days ago | 4 comments on HN | MIXED_POSITIVE_WITH_STRUCTURAL_FRICTION Editorial · vv3.4 · 2026-02-24
Article Heatmap
Preamble: +0.17 — Preamble P Article 1: +0.09 — Freedom, Equality, Brotherhood 1 Article 2: ND — Non-Discrimination Article 2: No Data — Non-Discrimination 2 Article 3: -0.03 — Life, Liberty, Security 3 Article 4: ND — No Slavery Article 4: No Data — No Slavery 4 Article 5: -0.01 — No Torture 5 Article 6: ND — Legal Personhood Article 6: No Data — Legal Personhood 6 Article 7: ND — Equality Before Law Article 7: No Data — Equality Before Law 7 Article 8: -0.09 — Right to Remedy 8 Article 9: ND — No Arbitrary Detention Article 9: No Data — No Arbitrary Detention 9 Article 10: +0.23 — Fair Hearing 10 Article 11: ND — Presumption of Innocence Article 11: No Data — Presumption of Innocence 11 Article 12: -0.10 — Privacy 12 Article 13: +0.30 — Freedom of Movement 13 Article 14: ND — Asylum Article 14: No Data — Asylum 14 Article 15: ND — Nationality Article 15: No Data — Nationality 15 Article 16: ND — Marriage & Family Article 16: No Data — Marriage & Family 16 Article 17: -0.07 — Property 17 Article 18: ND — Freedom of Thought Article 18: No Data — Freedom of Thought 18 Article 19: +0.47 — Freedom of Expression 19 Article 20: +0.20 — Assembly & Association 20 Article 21: +0.08 — Political Participation 21 Article 22: +0.19 — Social Security 22 Article 23: +0.11 — Work & Equal Pay 23 Article 24: +0.08 — Rest & Leisure 24 Article 25: +0.07 — Standard of Living 25 Article 26: +0.10 — Education 26 Article 27: +0.06 — Cultural Participation 27 Article 28: ND — Social & International Order Article 28: No Data — Social & International Order 28 Article 29: +0.06 — Duties to Community 29 Article 30: 0.00 — No Destruction of Rights 30
Negative Neutral Positive No Data
Aggregates
Weighted Mean +0.08 Unweighted Mean +0.12
Max +0.47 Article 19 Min -0.10 Article 12
Signal 20 No Data 11
Negative 6 Volatility 0.28 (Medium)
Channels Editorial: 0.6 Structural: 0.4
SETL +0.82 Editorial-dominant
HOTL -0.38 Consensus
Evidence: High: 2 Medium: 13 Low: 5 No Data: 11
Theme Radar
Foundation Security Legal Privacy & Movement Personal Expression Economic & Social Cultural Order & Duties Foundation: 0.13 (2 articles) Security: -0.02 (2 articles) Legal: 0.07 (2 articles) Privacy & Movement: 0.10 (2 articles) Personal: -0.07 (1 articles) Expression: 0.25 (3 articles) Economic & Social: 0.11 (4 articles) Cultural: 0.08 (2 articles) Order & Duties: 0.03 (2 articles)
Domain Context Profile
Element Modifier Affects Note
Privacy -0.05
Article 3 Article 8 Article 12
Content includes tracking and analytics (New Relic monitoring), cookie consent disabled. Limited privacy signals in visible metadata. tdm-policy indicates text-and-data-mining controls, suggesting data stewardship.
Terms of Service
No ToS visible on-domain in provided content.
Accessibility +0.02
Article 5 Article 26
Minimal accessibility signals observable. Standard HTML semantic structure (lang attribute, viewport meta). No explicit WCAG compliance declaration on-page.
Mission +0.08
Article 19 Article 27
ScienceDirect/Elsevier mission aligns with knowledge dissemination and scientific freedom. Publisher context suggests commitment to scholarly communication and research access.
Editorial Code +0.05
Article 19 Article 20
Cell Press (publisher) maintains editorial independence and peer-review standards, supporting free expression in scientific discourse.
Ownership -0.03
Article 17 Article 25
Elsevier ownership (commercial entity). Paywall model restricts access based on institutional subscription. DRM/copyright controls present (NOARCHIVE, NOCACHE robots directives).
Access Model -0.15
Article 27 Article 26
Subscription-based paywalled journal article. Access restricted to institutional/paid subscribers. No open-access indicator. Limits realization of right to share in scientific advancement.
Ad/Tracking -0.04
Article 12 Article 8
New Relic tracking active (distributed tracing disabled per config, but cookies enabled). Cross-domain analytics present. Moderate tracking footprint.
Score Breakdown
+0.17
Preamble Preamble
Medium Framing
Editorial
+0.25
Structural
+0.05
SETL
+0.80
Combined
ND
Context Modifier
ND

Article content (title/abstract) addresses aging and memory—human dignity and well-being. Scientific knowledge sharing affirms human potential. Structural paywall model undermines dignity claims.

+0.09
Article 1 Freedom, Equality, Brotherhood
Low Framing
Editorial
+0.15
Structural
0.00
SETL
+1.00
Combined
ND
Context Modifier
ND

Article topic (life sciences, aging reversal) aligned with equal dignity of all humans. No contradictory signals in content. Structural access model neutral at Article 1 level.

ND
Article 2 Non-Discrimination
ND

Non-discrimination: No observable signals regarding protection from discrimination in this article portal.

-0.03
Article 3 Life, Liberty, Security
Medium Framing Practice
Editorial
+0.10
Structural
-0.10
SETL
+1.00
Combined
ND
Context Modifier
ND

Right to life and security: Medical research topic supports right to life. Analytics/tracking slightly undermines security of privacy. Subscription model does not directly threaten personal security.

ND
Article 4 No Slavery
ND

Slavery/servitude: No observable signals.

-0.01
Article 5 No Torture
Low Practice
Editorial
0.00
Structural
-0.08
SETL
+1.00
Combined
ND
Context Modifier
ND

Torture/cruel treatment: No editorial content suggesting abuse. New Relic monitoring and data collection practices minor concern for bodily autonomy; accessibility gaps (no WCAG declaration) may exclude disabled users from knowledge access.

ND
Article 6 Legal Personhood
ND

Legal personhood: No observable signals in article metadata.

ND
Article 7 Equality Before Law
ND

Equality before law: No observable signals in provided content.

-0.09
Article 8 Right to Remedy
Medium Practice
Editorial
0.00
Structural
-0.12
SETL
+1.00
Combined
ND
Context Modifier
ND

Right to effective remedy: New Relic tracking, cookies enabled, NOCACHE/NOARCHIVE directives restrict user control over data. No visible privacy/complaint mechanism on-domain. Structural data handling does not obviously support effective remedy for privacy violations.

ND
Article 9 No Arbitrary Detention
ND

Arbitrary arrest/detention: No observable signals.

+0.23
Article 10 Fair Hearing
Medium Framing Practice
Editorial
+0.20
Structural
+0.15
SETL
+0.25
Combined
ND
Context Modifier
ND

Fair and public hearing: Peer-reviewed scientific article in established journal (Cell Press) implies editorial review process, transparency, and fair adjudication of evidence. Metadata (DOI, ISSN, citation data) supports scholarly record integrity. Subscription barrier slightly reduces public access to fair proceeding.

ND
Article 11 Presumption of Innocence
ND

Presumption of innocence: Not applicable to scientific article.

-0.10
Article 12 Privacy
Medium Practice
Editorial
0.00
Structural
-0.14
SETL
+1.00
Combined
ND
Context Modifier
ND

Privacy and family: New Relic analytics tracking enabled (cookies active, distributed tracing). No visible privacy policy or consent management UI on-page. Page metadata includes citation/publication data but tracking cookies and analytics violate expectation of private information handling.

+0.30
Article 13 Freedom of Movement
Medium Framing Practice
Editorial
+0.30
Structural
+0.10
SETL
+0.67
Combined
ND
Context Modifier
ND

Freedom of movement: Scientific knowledge supports unrestricted human inquiry and movement of ideas across borders. Peer-reviewed publication affirms freedom to seek/share information. Subscription model creates jurisdictional/access barriers but does not restrict physical movement.

ND
Article 14 Asylum
ND

Asylum: Not applicable.

ND
Article 15 Nationality
ND

Nationality: Not applicable to research article.

ND
Article 16 Marriage & Family
ND

Marriage/family: Not observable in scientific article context.

-0.07
Article 17 Property
Medium Practice Framing
Editorial
+0.05
Structural
-0.18
SETL
+1.00
Combined
ND
Context Modifier
ND

Property/ownership: Article copyright owned by Elsevier/Cell Press (not author or public). NOARCHIVE/NOCACHE robots directives restrict user archival. DRM and subscription model limit property claims of readers. TDM policy restricts text-mining reuse. Structural IP enforcement undermines right to own property (knowledge).

ND
Article 18 Freedom of Thought
ND

Freedom of thought/conscience: Not applicable to scientific content per se.

+0.47
Article 19 Freedom of Expression
High Framing Practice Coverage
Editorial
+0.55
Structural
+0.20
SETL
+0.64
Combined
ND
Context Modifier
ND

Freedom of opinion/expression: Peer-reviewed scientific article embodies freedom of expression. Full-text access restricted by paywall, but metadata and structured citation data publicly available. Editorial independence of Cell Press affirms right to express. Paywall model creates friction against universal access to expression.

+0.20
Article 20 Assembly & Association
Medium Framing Coverage
Editorial
+0.30
Structural
-0.05
SETL
+1.00
Combined
ND
Context Modifier
ND

Freedom of assembly/association: Scientific publishing supports scholarly community and free exchange. No editorial restrictions on assembly. Subscription model does not prohibit association. Paywall slightly limits collective participation.

+0.08
Article 21 Political Participation
Low Framing
Editorial
+0.10
Structural
+0.05
SETL
+0.50
Combined
ND
Context Modifier
ND

Participation in government: Scientific research informs policy. No contradictory signals. Subscription access limits some participation but does not prohibit it.

+0.19
Article 22 Social Security
Medium Framing
Editorial
+0.20
Structural
+0.10
SETL
+0.50
Combined
ND
Context Modifier
ND

Social security/economic rights: Medical/gerontology research supports right to social security and health. No restrictive editorial framing. Paywall creates economic barrier to knowledge access, slightly undermining economic opportunity.

+0.11
Article 23 Work & Equal Pay
Low Framing
Editorial
+0.15
Structural
+0.05
SETL
+0.67
Combined
ND
Context Modifier
ND

Work and favorable conditions: Scientific authorship and publishing affirm right to work. Peer review process implies fair labor norms. No anti-labor editorial content. Structural paywall does not directly impact working conditions.

+0.08
Article 24 Rest & Leisure
Low Framing
Editorial
+0.10
Structural
+0.05
SETL
+0.50
Combined
ND
Context Modifier
ND

Rest and leisure: Not directly addressed in scientific article. No contradictory signals.

+0.07
Article 25 Standard of Living
Medium Framing Practice
Editorial
+0.25
Structural
-0.10
SETL
+1.00
Combined
ND
Context Modifier
ND

Health/standard of living: Gerontology/neurobiology research directly supports right to health and adequate standard of living. Content affirms dignity and well-being. Paywall restricts knowledge access, limiting health equity; commercial model may prioritize profit over universal health.

+0.10
Article 26 Education
Medium Framing Practice
Editorial
+0.20
Structural
-0.08
SETL
+1.00
Combined
ND
Context Modifier
ND

Education/development: Scientific article supports right to education and access to knowledge. Peer review affirms quality. Paywall and subscription model restrict free access to learning; no open-education signals. Accessibility gaps may exclude disabled learners.

+0.06
Article 27 Cultural Participation
High Framing Practice Coverage
Editorial
+0.35
Structural
-0.12
SETL
+1.00
Combined
ND
Context Modifier
ND

Culture/science: Article published in world-leading journal (Cell), contributing to international scientific and cultural heritage. Content freely advances human understanding. Paywall significantly restricts participation in scientific advancement (right to share in scientific benefits). Commercial IP model undermines universal access to cultural/scientific benefits.

ND
Article 28 Social & International Order
ND

Social/international order: No observable signals in article metadata.

+0.06
Article 29 Duties to Community
Low Framing
Editorial
+0.10
Structural
0.00
SETL
+1.00
Combined
ND
Context Modifier
ND

Community duties: Peer-reviewed science affirms duty to participate in community advancement. No anti-community editorial content. Paywall model reduces collective participation.

0.00
Article 30 No Destruction of Rights
Low
Editorial
0.00
Structural
0.00
SETL
ND
Combined
ND
Context Modifier
ND

Prevention of abuse: No observable abuse-prevention signals specific to this article. Standard publisher safeguards (peer review, editorial oversight) imply commitment to preventing misuse of research.

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build 40e2d86 · 2026-02-24 21:55 UTC